I have the Harmony One, and love it, its does every component that I have excpet the PS3, which is blue tooth. THe setup was super easy. At first I thought I would be overwhelmed with the setup, but all you do is throw in the disk into your PC, it asked a few questions and BAM...your done. Maybe 15 minutes your first time through.
I believe Harmony has several models that do all the basic things, the ONE has a color touch screen which is nice and it comes with rechargable batteries and a recharging docking station. Wow, this is starting to sound like a commercial, so I will stop now. I will say that I do not have any experience with any other brand of remotes, so I can not attest to how well the Harmony performs over the others.