When I bought my Aperion VAC-532 center channel, I asked Aperion's support (which is fantastic, btw) how it would fit with my speaker setup. They told me it should fit well with any speakers I might have. I took their word for it.
Then, when I upgraded my fronts and surrounds to Def Tech ProMonitor 1000s (retaining the Aperion center), I talked to Def Tech's support (which is also very good) about the blend between the 1000s and the Aperion. They also said there should be no issue with integration and cohesion.
When I set everything up and calibrated SPL and phase, I didn't get a wholly coherent sound stage, but couldn't figure out why. A few months later, I decided to run a front-align EQ calibration routine with my receiver (humble Pioneer VSX-815) which aligned the Aperion center with the front left Def Tech as closely as possible. First of all, I couldn't believe how much different the EQ curves was. I had to change the center -6db@100hz and +6db@240hz to get them even close to the L/R. WOW. What a difference that made to the sound stage! The sweeping of point sounds from left to right was much smoother and was no longer disjointed and distracting. Stereo music through Dolby Pro Logic IIx was substantially more cohesive.
In addition, the surrounds, despite being the exact same speakers as the L/R, also received significant EQ changes to compensate for placement in corners, etc. That also made a huge difference; the rain scene in the film Baraka became stunning.
The reason for this post is two-fold: 1) Why isn't more emphasis placed on EQ calibration by speaker manufacturers and set-up guides, and 2) If you haven't done an EQ calibration on your system, please do consider it! You could reveal a potential of your system you didn't even know was there.