Shieze,
I have the same setup as you in my current house. As you can see from my profile, I, too, am new to this forum, but I provide my opinion simply FYI.
Right now, I've got the speaker wires hugging the wall and floor and stapled to the baseboard with wide staples, obviously without actually stapling through the wires! And where the wires cross walking paths, I've got an area rug/runner covering that portion.
As for speaker placement, I went out and bought speaker stands for the rears and have them on either side of the sofa.
I'd advise against going through the drywall unless you're planning on living in that house for more than 5 years.
I'm an aspiring audiophile as well, so my info isn't quite what I'm sure you wanted, but hopefully it's somewhat helpful.