The ED A5s-300 is a very different sub than the others on that list, I wouldn't list it with the others unless you were willing to get two. With two though, you get a discount, $1K shipped, and I think such a system would be very competitive with any of the other subs you mentioned, something worth considering.
I have the A3-300 and a couple VTF3's so I can tell you how they compare, but I can only guess about the others. They are both very good subs, the VTF is certainly higher performing but it is also more expensive. It's tighter, it reaches deeper frequencies, and is solid as a rock even when it's rocking hard. It also has a nicer finish. However, the A3 is a bit smaller, and can mostly keep up with the VTF in output above very deep frequencies. It also has very good sound quality. The PB12 looks a lot like the A3 except tuned a bit lower. I know that would be a rockin' sub too.
I think the A5-350 would be a blast, it ought to have the most output and overhead. It will fill that room just fine, but to be honest, any of those subs will, as long as you take the time to place them correctly and dial them in. I would expect the A5 350 to have the most slam and impact, however.
Switching modes on the VTF is not a big deal, you just take that foam plug and flick a switch. If you decide to go with that sub, you will eventually find which mode you prefer and keep it there. It's also perfectly sized to double as an endtable, and with a side-firing driver, that is bass you can feel. I believe the Outlaw LFM EX even has the option of a plexiglass top, which also encourages its use as an endtable. By the way, although the LFM and VTF are a lot alike, they are not identical. The VTF has larger ports, which enable it to play a bit deeper than the LFM, from what I have read. Still, I think the performance differences would be negligible in most circumstances. Don't wait too long if you want the VTF3, I don't think it will be on sale much longer.
In my opinion, there is not a wrong choice between them. Any of these are great subs and will outperform equivalently priced subs at retail stores. The only way you can lose is by going to electronics store and buying whatever they have without doing any homework on the matter, and you have already cleared that hurdle.
