It's preferable to have the subwoofer in front of you and is even better if you can put it between your front left and right speakers.
Corner placement of the subwoofer will improve efficency and loudness but may make the sub sound boomy. Typical room dimensions will lead to standing waves and uneven bass response through the room. The only way to solve this problem is to have your room acoustically treated. A work-around solution that THX use is to roll off bass gradually below 50 Hz (THX equaliser). Having more than one subwoofer can help smooth out bass response, as the two (or more) subwoofers will tend to excite different standing waves in the room.
The only thing I know for sure about cables is to keep them as short as possible! As to how different they sound, the only thing I've ever seen for cable reviews are descriptive measures of performances. From personal experience I know video cables make a difference. Audio cables probably have a less noticeable effect. I think cables are a bit of a rip off anyway. It probably is still worth buying any reasonably good quality cable, just don't go over the top with the price (10% of total system budget on cables is a well-known rule of thumb).