If it's not an extreme distance, the wireless should work but you'll need to make sure it won't need to pass through a big refrigerator, chimney, masonry walls or other dense materials. Make sure you can return it if it doesn't work, too.
The hum is from not using shielded coaxial cable. If you have a basement below those rooms, you should be able to run a coax but that won't necessarily eliminate the chance of hum because of the distance. 50 feet is pretty far for a wireless sub transmitter and receiver.