I have quite an impressive sounding setup for what it is. I have a pair of KLH 9915's (15", ported, 4-way) powered by a Denon PMA-300V integrated amp (55 W per side). These 9915's are loud as hell (92 dB sensitivity is pretty good) and along with the higher-quality Denon amp sound very, very nice.
Since you can afford quite a bit more than what I paid for my setup, I suggest going with a higher-end pair of floorstanding speakers with 2-12" or a 15" and a sensitivity above 90 dB or so, and as much power as the speakers can handle. If you want a sub/sattelite setup instead, I suggest going for larger sattelites (at least 8" 3-way) with a higher sensitivity as well so you don't lose that low midrange punch.