I was actually referring to optimizing placement of just two speakers (I didn't make that clear.)
There is a distance from the walls that gives the best balance between bass strength and bass clarity. There is also a best relationship between speaker position and seating position for imaging (the equilateral triangle is a good starting point, but not necessarily optimum.) Finally, there is an amount of toe-in that gives the best balance between image size and image focus.
I adjust these variables by trial and error, but I never know for sure that I have arrived at the ideal combination.