What speakers, how large is the space (that matters when considering the power used and needed) and how loud do you want to run it? If it's for background music in a commercial space, you'll need a commercial amp because the warranty on consumer grade equipment doesn't cover commercial use. Personally, if I was doing a system in a large space, I would either use all dual voice coil ceiling speakers or a mono system, like this:
http://www.parts-express.com/pe/showdetl.cfm?Partnumber=246-524
or this:
http://www.parts-express.com/pe/showdetl.cfm?Partnumber=242-904
You're not too concerned with sound quality, or you'd be using something other than MP3 (unless you plan to use .wav files) and stereo separation isn't needed in this type of application. What is needed is good sound coverage and dispersion, which is why systems for wide distribution are usually mono. You want the sound coverage to be even enough that you could move through the whole place and not hear a difference in sound, from place to place. If the ceiling is high, don't use regular ceiling speakers- you need to use speakers with a definite dispersion pattern and place them so the patterns mesh well.