Is this a question about wiring your room, or just the speakers?
If wiring the room, and you intend to do it behind walls, and put a great deal of effort into the wiring in the room, then running 14/4 (or 12/4) wiring behind walls in the case you ever decide to bi-wire/bi-amp is not a bad way to do things. Wire, relatively speaking, is inexpensive from decent sources such as Monoprice.
If you are just talking about how to wire your speakers up, then read the advice and links from the previous posters.