Wow, this thread is just too good to give one answer.
How about "Dragonsong" (Or any of the Dragonriders of Pern series) by Anne McCaffrey with Alex Proyas directing. The guy can handle subtlety (Dark City) and also does big Hollywood too (I, Robot); his surround mixes are awesome as well.
On the subject of Asimov, any of the Robot novels would be killer ("Caves of Steel", "The Naked Sun", "The Robots of Dawn"), these works are still surprisingly relevant and I would like to see Michael Douglas as Elijah Bailey and a 1/2 actor 1/2 CG to do R.Daneel -- who better than Peter Jackson to do this.
Lastly, how about something groundbreaking like "Banish your Belly" by Kenton Robinson starring Christie Brinkley, directed by Paul Verhoeven with lots of gratuitous crotch shots, explosive hernias, and a studio mandated voice over narrative a la Blade Runner.