The sound waves for the lowest frequencies the typical sub can produce are far longer than that room, so as I said, facing them 45 degrees to the listening area will make no difference at all to how well the lowest notes develop. It would be fine to mount them up high, but that doesn't mean it will give you the best performance. When you say "standard", sound behaves the same in every room, but every room is different so your results are going to be entirely dependent on the way the sound reacts to your room and based on your picture, you need to take into account the rest of that open area as well.
What might work is one on the far wall (front) and one near your seating position. If they are dual, side by side subs, you could stand them on end to get some floor space back, then try various positions in the room that give you the best performance. You could maybe also put them both behind the couch.