Well before I start randomly throwing out recommendations (I can feel my famous budget system stirring...), a few questions. NO ONE EVER ESCAPES THE SPANISH INQUISITION! (...okay I'm Polish, but...Monty Pyton is funny...)
-How big is your room?
-What's your budget?
-What kind of constraints are there with the WAF (wife acceptance factor)?
-What percentages will be using your system for music/movies/gaming?
I have plenty of ideas, but what I throw out will be determined how you answer the questions above. Choose wiseley...
And lastly, you need to get out and listen! Find the local hi-fi and mid-fi dealers in your area and start listening to speakers. You'll find out what kind of speakers you like very quickly. Just take along some of your favorite music and plop down for some listening sessions. I don't know what kind of music you listen to, but I really like using these CD's as references:
Donald Fagen - The Nightfly (excellent fidelity, one of the first digital recordings)
Steely Dan - Gaucho (Hey Nineteen is a brightness detector...your ears will bleed if a speaker is too bright for you)
Pink Floyd - Wish You Were Here (Shine On You Crazy Diamond is great to test that WALL OF SOUND thing)