Do you have a box design using the drivers' TS parameters? What models of drivers are you working with?
Are you building the box ported or sealed? What is the F3 of the tower?
What is the volume of each enclosure for your 12" and 6.5" drivers?
Do you have a designed crossover? If so what are the crossover frequencies and slopes of each crossover?
Are you bi-amping the tower, running seperate amplification to your 12" drivers and your 6.5/Tweet drivers?
If your answer to any of these questions is
then I also suggest slowing down a bit and trying something like a 2-way design already documented and proven for your first build.
Your welcome to answer all the above questions but that was not my intent, they are questions you can ask yourself when you are trying to fall asleep at night