Unfortunately, rarely is the best place for your mains to image properly the best place to reproduct bass. That's why the standard recommeded setup is all speakers set to small and cross over at about 80Hz. That way, you can set the subs for best bass response without compromising the mains positioning.
If you run the sub AND the mains large, more often than not, you'll end up with a lumpy mess for frequency response due to cancellations between them. Once in a blue moon someone will get lucky. However, this still doesn't provide the other benefits:
- reduced load on main speakers
- reduced load (extra dynamic range and headroom) on the amp driving the mains.
The Harman research suggests that 2 subs set in the center of 2 opposing walls is generally an excellent placement and will help smooth out several of the room mode interactions.
Bryan