Trying to treat blind is an absolute folly! Short of measurements, experimenting with incremental placement changes would help... but take a loy of time. You would need to log avery change you make from front wall, side wall, toe-in angle, etc.
If you have Audyssey XT32 and their App, you get, at least, a good representation of the "Before" sweep. I was able to use this to fix a -20dB Suck-Out from a +10dB Peak! (Yes, a-30dB change, all because the Front Left Speaker was right at a cancellation point for a certain frequency at the 1/2-wave. I moved it 1.5" amd changed toe-in slightly... boom, it bacame a room artifact with at -10dB.
Measurements are key to understanding what is happening in your room!