I have Monitor Audio 7i's in front, FX/i's as surrounds (wired as Bipoles) with a 12i center. I use a Denon 3802 as a preamp & a pair of Hsu TN1220s run off the 500 W amp. I have a variety of DVD & CD players, and it's been a bit of a transport-go-round as I've tried a number of them from Sony, Philips & Pioneer. The cabling is a mix of Zu & homemade.
So far I haven't heard the S2, but it should have similar capabilities as the 4i's, and they're fine mains, so long as you have a sub. The new S2 actually plays a bit lower than the 4i & so should blend well with any good subwoofer.