Welcome to the forum!
Interesting question. Do you already have both systems, or still contemplating the Z-5500?
In the spec sheets, the MX5021 satellites are listed as 6 ohm, whereas the Z-5500 satellites are listed at 8 ohm. If the amp in the Z-5500 system isn't designed to handle the lower impedance of the MX5021 speakers, then you could run into issues. Personally, though, I doubt that you'd damage the amp in the Z-5500.
Something else that you could do is hook up both systems, unless you're running a digital connection. If you are using the 5.1 analog connections from a computer, then you could feed the front speaker signals to the MX5021 and run the center, rears, and sub signals to the Z-5500. Set up the bass management on your computer, and that might work out really well.