This question comes up fairly regularly, and the usual response is that you want the tweeters inboard closest to each other. I don't think there's any theory behind that. Maybe it just looks like they will image better that way. My best guess is that it doesn't make any doo da difference--at least I can't hear any. But, in principle I think you would want to orient the tweeters for the smoothest off-axis response between the speakers. My Affordable Accuracy monitors, which have mirror-image offset tweeters, measure flatter off axis to the left when the tweeter is on the right, and vice versa. So that would argue for placing this particular speaker with the tweeters furthest apart. Other speakers? I have no idea. Glad I could help.