i'm not too sure about this but it looks like in system pref's you have to pick the main audio device output and then all audio signals are routed to that. and so what i am afraid of is it's one or the other (hdmi or usb) but i don't know if it actually works like this.
update: got my answer at computer audiophile forums, a great place (thanx guys)
"Yes, you can.
You do have to change interfaces.
However, what I do is this:
I play movies via iTunes or Front Row, and have them use my "default" audio out, which I set to HDMI.
Then I play music via Audirvana or Decibel or BitPerfect, and set their preferred audio out to the USB (in my case Halide Bridge). Then it is fairly seamless.
If you option-click the little speaker icon thingie in the menu bar, you can easily toggle between audio output interfaces that way."