Mass-loaded vinyl, or MLV (Dynamat), around the blower casing will not help if the sound is primarily coming through the vent. Also, with only 2 feet between the blower and the vent, there's not much to work with. Even something like Chris is suggesting might have limitations being located so close to the blower intake. It all depends on how relatively "straight" such a construction can be. Acoustical duct treatments work best if the air has several duct diameters of straight run before encountering any transitions. A plenum such as Chris described still needs to have a fairly straight run for the airflow when it is so close to the intake. If such a construction (again, so close to the intake) becomes too zig-zaggy, it may attenuate blower noise, only to replace it with turbulent airflow noise. (Not to mention that it might have a negative impact on blower performance / efficiency.)
What I would suggest, if there is space available, and assuming the intake is located high on the wall (as they often are), is to run a acoustically-lined duct clear across the room. This need not be the same dimensions as the air intake, but should have roughly the same (or larger) cross-sectional area. For example, if you have a 24"x24" intake, a duct that runs across the ceiling that's 10" high x 60" wide would work. Each linear foot of acoustically-lined duct will attenuate roughly 3-5 dB of broadband sound (with less attenuation at low frequencies; more attenuation at high frequencies). An opening on the opposite end of the duct - now many feet away from the intake - will still pull the right amount of air into the unit, but with much less noise.
There are other approaches. The performance of anything will depend on how much sound is coming out the vent (probably a lot, relatively) versus what's coming through the wall. There might be a point where the vent / duct noise is attenuated to a point where the noise coming through the wall becomes the annoying part.
FWIW, there is a good write-up on HVAC noise located
here. (I developed much of it back when I worked for Auralex.)