You can go a lot farther than 25' with coax or with Cat5e, for that matter. I have a Cat5e going from my main stereo to the one in my garage, at least 50' away. RCA plugs soldered onto the garage end and a Keystone insert that has screw terminals on the backside and accepts a 3.5mm plug on the front. I had RCA plugs on the source end but I wanted to add a cable to the basement stereo.
You can't go too long with a high impedance line level run, though. If you need to go farther, use some kind of line driver or audio distribution amp. If you can centrally locate it, relative to the farthest/closest speakers, it will work best.