Jaxvon pretty much nailed it here. If you can avoid running your speaker wires with power lines, do it. If not, try to cross at 90 degree angles and if you have to run them parallel to each other, try to keep them as far apart as you can.
As for terminating your nifty new 14ga wire, I prefer to use banana plugs for the ease of disconnecting and reconnecting when you have to. Plus I really like the way they look. Honestly though, it really depends on what you prefer, you're gonna get the same quality of connection as long as either is done right.
Jack