One concept to keep in mind is that smaller main speakers and use of a subwoofer for bass (under 80 or 100 Hz, say), is essentially using a 3-way design, in that there are two sets of crossover frequencies.
Also, you might view the port (or passive radiator) on speakers that have these design features as being a pseudo- third "driver" as they will each have their own frequency response that needs to be well-integrated with the mid-bass speaker (albeit without an electrical cross-over circuit).
Given that modern drivers are capable of pretty broad frequency response, I am tending to lean to the "fewer crossovers is better" school of thought, but clearly there are good and bad sounding speakers in both camps. I think it can also be important to avoid crossovers in the "low to medium" midrange area where there are a lot of fundamentals (say from 100 Hz, or maybe a bit higher, on up to maybe 1000 Hz.). Most 2-way and 3-way designs have the mid-bass to tweeter crossover somewhere around 2 kHz. or maybe as high as 3 kHz., where you are already dealing with harmonics (not to say that these aren't important!)