Let's see... I've got to control the blinds, lights, plasma, projector, motorized screen, fireplace, dvd player, dvd changer, cable DVR 1, cable DVR 2, PS3, HD DVD, XM, FM, digital music server, switcher, receiver, amplifiers...
I have Crestron - and I actually use two remotes in the family room - a 10" wi-fi panel and a handheld remote. The handheld is flawless, as is the 10" but when it falls on the floor it doesn't make me cringe.
The Master Bedroom has a handheld Crestron (MX-850 clone) and the kids playroom has a 10" touchpanel.
About a dozen other rooms have 12 button keypads.
All about Crestron for sure!