It's not the system so much that you need to worry about being able to resolve minute differences. Even rather budget oriented stuff will be able to do that.
The real difference is simply your ears. Most people simply cannot hear the difference in reality. Our hearing is not good. It's poor really.
You're overall not limiting your experience no matter what your equipment is via MP3 with 320kbps data rate. Any difference is only measurable and frankly not audible for most people (it's hard to say all, because there's always that one person who claims they can, but you know just as well they would fail to be 100% correct in a blind 100 track listening test, but I digress... and I know better than to use absolutes).
That said, capacity is so inexpensive these days, if you're not hurting for storage space, just get lossless and don't even think about it and instead focus on the total system (which includes the room, if using speakers).
I think we all come to this at some point in the audio journey. I put it to rest for myself when I was using (at the time) high end headphones and excellent equipment and actively looking at overlay waveforms and listening A/B style to various places in a track where I saw a difference in the waveform. There were moments where I thought I heard a difference. But using truly blind A/B testing (software) I couldn't recreate that experience in just any track. Ultimately it was my brain, we like to predict things, its what brains are good at, and they're great at being incorrect. I use mostly FLAC because I have no capacity limits at home. But I use MP3 320kbps for my mobile devices that have greatly reduced capacity. It's a personal thing. Knowing you're using compression with your audio while trying to have excellent physical speakers seems like going backwards, but it's not. It's a cerebral game and we can easily fall into thinking that way when not being objective about it. So for some, it's part of the ritual side of things, and if that makes them happy, good for them. You do you.
Very best,