The best audio system would be to have someone custom build you speakers voice precisely for your room with the best drivers, amps, and treatments in the world. Such a system would be very costly though and I'm certain you have a budget of some kind.
Speakers worth considering
Salks, Ascends, Pioneers, Philharmonics, SVS and others mentioned here of course
For Subs: Funk or SVS.
For receivers: Avoid Onkyo and Sony and you should be safe.