Alright, a couple basic questions and things to try -
Questions:
How many speakers are you powering through Zone 2?
Are you going through any amplification or powering directly from the receiver?
Which terminals are they hooked up to? - I'm assuming L and R surround speaker (B) ports, please confirm
How do you connect to your speakers and receiver? Bananna plugs or direct insertion into terminals
Things to try:
Check connections - remove and reinsert wires if bare into receiver, ensure wires haven't pulled loose in bananna plugs if those are used
Swap the connections for these speakers to the main zone front R\L terminals, ensure the channel levels for both are set the same, then play a test tune or tone to compare volume between the speakers. If the speakers now sound the same, it's a settings or receiver hardware issue.
Also try moving your main zone front R\L speaker connections to the zone 2 connections and see if they exhibit the same discrepancy. If so, you've confirmed it's a settings / receiver issue.
Try those things out and let us know. For reference, your manual can be found here
http://usa.denon.com/DocumentMaster/US/AVR4306_DFU.pdf