If the length of your interconnects from pre-amp to amp are long, then yes you will notice a difference, but if they are only a few feet, then you most likely will not notice a difference.
Balanced connections work by sending the signal across 2 (3 if you count ground) wires, one of the regular signal, and one of a mirror image.
The idea behind this is that if interference does affect the signal, it will affect both at the same time in the same way, so it's not the signal that's important but the difference between the 2 wires (divided by 2).