What's your budget? And what will yo be using them for? I ask because I currently have a 2.1 system (no sub yet) but had a powered Cerwin Vega Sub with it for awhile. My setup is in my sig and I cannot say enough how much I am impressed with the sound of my little Paradigms. They were $800, then another $500 for the receiver, but damn are they crisp and full.
I am about to start building my girlfriend a system, and I may be using the Axioms to start her off with.
If your budget is not that big of a deal, I would go Yamaha RX-V2600, 2 Paradigm Studio 40's, and your SVS sub of choice. By that right there is easily 3 Grand.
I have been watching audiogon and ebay for some deals. A brand new set of Studio 20's like mine went for $455 plus shipping, and there were a set of 40's that went for right over $700.