You can use one wire with 4 conductors to wire 2 speakers. By convention, you would use red(+) and black(-) for one speaker and green(+) and white(-) for the other speaker. Then of course you match the other ends of the wires to the receiver - whichever color you used for positive goes to the positive speaker terminal on the receiver (which will always be colored red) and whichever color you used for negative goes to the negative speaker terminal on the receiver (which will always be colored black).
OR
If you have 4 speakers and 4 4-conductor wires then you can just use one pair of the conductors from each wire for each speaker and just cut or tape the ends of the others. Those extra wires not being used for speakers can be used for anything but won't be of much use unless the other 'thing' you want to use them for is nearby the speakers.
Incidentally, if those wires were run as part of a pre-wire in a new home, they are most likely 16/4 which means each conductor is 16 gauge and there are 4 of them (red, black, green, white). It's just wire and can be used for your speakers, security system, touch pads, remote control - whatever.