For sure what jinjuku said, just double it up for 2 subs. Also, for wood I'd definitely use 3/4" MDF.
As far as calculating the enclosure size, it's LxWxH/1728 on the inside of the box. Remember, you're using 3/4" mdf so you'll basically subtract 1 1/2" from the outside box's dims.
For instance, if I had made a subwoofer box that was 14"deep x 12"tall x 13"wide (inside the box), it would be 1.26 cubic feet- that would be for one sub. If I were running 2 subs, I'd just make the box 26" wide w/ the same height and depth and it would then be a 2.52 cubic foot box; good for 2 subs that required 1.26 cubic feet each.
You also have to subtract a teeny bit of airspace for what the sub uses up in the box; your subwoofer manual should state that info.
The info I just gave you is fairly generic, but a good rule of thumb. Sealed boxes are the easiest to build FYI, but ported sub boxes generally give you a little more boom. I was always particular to the sealed boxes myself for subs in a car for 2 reasons, easier to build and they take up waaay less space. A ported box requires a lot more air space, so its a lot bigger box.