I like the Neo 6 for CD music as much as I liked running Pure Direct.. it seems to sound very clear. the Music hall ones worked very poorly, to me, at least, on the CD's (Martina McBride- White Christmas) and concert dvd's I tried (Elton John and the Moody Blues and the voices picked up a strange reverb), but the general cinema worked just fine for the same purpose.
I used the THX setting on the Star Wars trilogy and the spectacle setting for Fifth Element and Big Trouble in Little China. I couldn't tell any difference between SciFi and Adventure. I guess I'll stick with THX for encoded disks, but go with the spectacle for most of my movies.
I don't really need 58 settings, but at least the three I plan to use most were included in that 58.