Several years ago, I had built an 8 cf enclosure for a 15 inch subwoofer. It was placed in the center of the living room and used as a coffee table as well. I still remember its smooth low frequency response. Of course, it was well designed but this smooth response was also not affected by room gain.
IMO, the center area of a room location is the best spot when you can do it, especially for an audio system using only one subwoofer. It's worth a try!