Differences in DACs do exist. I level matched a Benchmark DAC-1 with my ex-Outlaw 990 preamp. The differences were not utterly dramatic, but they were present. If you're experiencing a drastic difference, then something else is wrong.
I'm not sure exactly how you have it set up. You're pushing a MF DAC with a DVD player's digital output. Then, from a Mac, you're sending a digital signal via USB? Is that how it's setup? And then, when you listen to the same material, you hear a difference?
I did something like that as well, and I found a problem with the sound card setup. Since you're going USB out, you may not have a sound card setup to consider (or maybe there's some other settings available for USB output; I've never done USB out). Is it possible that the program you're using to play the audio (Winamp, in my case) has some type of effect or something similar?
Anyway, I too had a drastic difference at one time, and I resolved it to computer settings. Once that was resolved, the differences were much more subtle, but still present. Additionally, I fed the Benchmark and the Outlaw with identical signals from the DVD player (well, I used optical and coax separately from the DVD player when listening), and differences were still present. No, I didn't do it DBT, but levels were matched, and I could hear a slight difference.
Good luck!