The pre outs should be live with that model and work for any channels. Do not connect speaker wire to terminals corresponding to channels that are being powered by an external amp by way of pre out ports. The X6400H processes and powers 11 channels and has but 11 channel speaker terminals. You cannot assign pre outs with this model like you can with the X6700H. That model processes 13 channels. While it has 13 speaker channel terminals, it can power only 11 and the user can select to have an external amp power the Fronts or Height speakers. This is similar to the X4700W that processes 11 channels, has 11 channel speaker terminals but can only power 9 of them. That just can't be done with the X6400H.
So, with amp assign at 11.1, you should be good to go and just connect the X4200 to the X6400H using the Front Pre Outs and leaving the Front Speaker terminals of the X6400H unconnected. As was mentioned, the X4200W should be in Pure Direct or Direct mode to avoid processing of the two channels it will power. You can leave it in Direct mode so you have a front panel display and rename the source input to "FRONTS."