Per this website:
http://www.gamefaqs.com/boards/939643-starcraft-ii-wings-of-liberty/55783873
No Game I know could utilize lossless HD codecs. Games work differently than movies - You know since the sound in game is interactive and depends on your actions.
SC2 have some sort of bug with 7.1 sound. They suggest to change it to 5.1
btw: I could pretty much guarantee with high degree of confidence that blizzard DID compress SC2 game sound with lossy compression.
Make sure to configure your sound setup as this Blizzard guide shows:
http://us.blizzard.com/support/article.xml?locale=en_US&articleId=21526
btw: I don't know it's changed, but back in the day - you HAD to have EAX support on your sound card to have multichannel audio in game, unless game converts all it's sounds to Dolby Digital - and this is very rare.
In my opinion your best chance to get 5.1 or 7.1 sound in games you need proper external sound card, not just dac interface.
http://us.store.creative.com/Sound-Blaster-XFi-Surround-5.1-Pro/M/B0044DEDCA.htm