If you're using a tower in the front as your center, I would think your biggest concern for it to sound as good as it could is making sure it has adequate space behind it. For e.g., the towers that I have need 4' from the wall to sound their best and that just wouldn't be possible with how my room lays out and where the entertainment center is. If space behind it isn't a big issue with your particular speaker type, or if you have adequate space, I say go for it.
If its a traditional center channel, I'd also recommend a stand of sorts. The closer you can get to ear-height, the better in my opinion. Angle it up towards your ears with a wedge if you can't get it there with the stand alone. I know PSB makes one that comes with their Synch One C that works slick for my application. If not, I'm sure you can have one made for you easily enough. Call someone that works with plastics, rubber etc...
Another option is putting your speakers behind an acoustically transparent screen.