Most people want to wire for more than 1 sub. I suggest wiring for four subs.
I know that may not fly with the lady though. The reason is you can always move your sub or subs anywhere you want. 4 subs is probably overkill for your room and isn't necessary if you have 2 great subs. Of course it never hurts

. But I would only do 4 if you are doing a DIY option. Even then I would only use two. Usually that is more than sufficient.
At least wire the front and back or the sides
For wiring I suggest you drop enough for an 7.1 and maybe one for a 6.1 as well. Make sure you put it in the right spot for acoustics. Don't mess that up. I think there is room modeling software to help. I think a great 7.1 setup is awesome for movies. You get amazing effects. I watch 2 movies every saturday on my 7.1 setup because it's so amazing.
If you can treat your room do it.