The 501 is rated at 6 Ohms so running speakers at 4 Ohms "may" be an issue. Still can't really see any reason for 2 centers though. Maybe if your trying to fill a huge room? If you have a bunch of the LX5's, I would just try it and see. With just the Onkyo, I would run them in parallel. Is the guy you quoted saying that he is running one center speaker from a receiver and the other center from a seperate amp? If so, that sounds like a not so good solution. Different amps drive speakers differently. It would seem like it would be very hard to match the two speakers with seperate different power sources, if not impossible.
I would just stick to a standard setup with one center. There is a reason it's considered standard.
Without knowing who the person is who told you this info, I can't vouch for his credibility but it sounds like more trouble than it's worth. Many times, simple is better. Especially in Audio.
Shinerman