Merely anecdotal, I know, but when I got my Monitor Audio GS60's, I very easily discerned some sort of "break-in." I took delivery on a Thursday morning--I had taken the morning off from work to meet the FedEx guy; I had a planned trip, w/ my flight leaving late that afternoon. I unboxed the GS60s, set them up, and started playing music through my primary source--an Apple TV feeding an external DAC. The sound wasn't horrible by any stretch, I thought it sounded very good. I listened for almost 2 hours before I left for the airport. I left my system running--had my settop box tuned to a digital jazz station.
I returned from my trip the following Sunday afternoon. I started playing music through my ATV again (the same Porcupine Tree album I had listened to on Thurs), and wow!! Everything just seemed tighter. I know, aural memory sucks, but in my case at least, it surely wasn't a situation where my ears simply got used to my new speakers. Of course I realize that placebo is still a possibility (probability?), but I have no agenda, no built-in reason to want to hear a difference. Juts my experience this last go around....fwiw.