At the back, there are too round shap knob, like a small volume control dial, but they are for gain adjustment.
There are no markings, no clicks either when you turn them. So if you adjust say, the left channel by 10 degrees anticlockwise to lower the gain, you end up with the following:
1) can you be sure you could turn the one of the right by exactly 10 degrees? I doubt you can, even if you can, there is no guarantee the two channel's lowered gain will match.
2) you don't know what the gain is vs the dial's position, you only know it will be 29 dB when set to maximu.
You can of course take various measurements, or use you PC, REW etc., to try and level match the left and right channel using the controls on your preamp and make further adjustments to those knobs (better to have one fixed, just move the other to match the output) while measurement the output voltage with a good multimeter and/or mic, spl meter etc. It then becomes basically a trial and error process.
That, to me, is a lot of work for nothing in your case. If the gains are selectable via switch/relay (just an example), such as 29 dB, 26, dB, 23 dB, then in theory there may be benefit to lower it to say 26 dB in your case, to minize noise. The A21 is not silent, neither is your AVR, but in my experience they are closely matched, the A21 seems a little noiser but that's only because of the large toroidal transformer that will hum as long as you have the amp powered on. You may hear it from 1 inch, or up to a couple feet depending on how sensitivity your are to the 60 and 120 Hz hum from the transformer. The AVR-X4400H's small power transformer is not audible when your ears touch the chassis, in a very quiet room. Speaker hiss should be inaudible unless you turned the volum close to +18.
The bottom line is, you have nothing to gain by turning down the gain. If you have one of those AVRs that measured with low SNR, low SINAD dominated by noise, then you may want to turn the gain down but it still depends.. There is really no clear one size fits all answer to your question, but in your case the answer is, leave them at maximum.
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