This is the kind of question that is entirely subjective. Presumably, you have listened to the Studio 100 v5 and have an opinion on how much better it is than your Studio 60 v5. Is the difference worth the cost? depends on your financial situation, and on how much you personally value the difference in the sound. While you are thinking about replacing your speakers, you might want to audition some other speakers from different brands, to see if you would not prefer something else.
Also, since you love what you have, you may decide to forget about listening to anything else, and be happy with what you have.
I was planning on doing that when I had Aurum Cantus Leisure 2SE (original U.S. version) speakers, which I love, but I heard some Apogee Stage speakers and decided that they would be my main stereo speakers instead. I still use the Aurum Cantus speakers in my home theater, and have no plans on upgrading them. But I do not want to go back to them for my main 2 channel stereo.
For what it is worth, I would not guess it to be worth upgrading from the Paradigm Studio 60 v5 to the Paradigm Studio 100 v5, particularly since you have a subwoofer for the deeper bass anyway. But my guess isn't really of any importance in your decision. But if you are thinking of changing your speakers, I think you should listen to many different models to be sure that you really want the Paradigm Studio 100 v5 speakers instead of something else. Granted, it would be less convenient, since you probably will not get the same trade-in value with another brand, which might make it better to sell them to an individual if you were to decide on another brand of speaker. But I do think that it is a really good idea to think about all of one's options when one is considering an upgrade, rather than just going with a previous thought on what might be best.