Another thing that needs to be taken into consideration is the sub design.
Ported. If so, front or rear?
Down firing.
Front firing.
Sealed.
So, not only does it depend on the room, the sub design will have alot to do with how it performs it what location.
My sub is front firing, and ported in the front. It performs best in the left corner of my room. If the port(s) were in the rear, it may not work so well in the corner.
Don't know.
I agree with AVRat and Scott about "crawling for bass" from the link provided by AVRat. It works well. But, the outcome all depends on the sub, room, and preference.