I've had two Pronto remotes and the Harmony was like a walk in the park compared to them both. The setup was just more my speed, slow and easy, and its just my personal experience. YMMV.
Yep, totally agree.
I had the Pronto TSU-3000 and the one handed TSU-500.
Both were great remotes, but the Harmony I have now (880), was by far the easiest to program.
And, yeah I am fairly good with computers and remote setups.
The only thing I can say bad about the Harmony, is that it feels really cheaply made when compared to the Pronto remotes (that I had)
Basically, if a person is intelligent enough to make a post here, then you should have no problem setting up a Harmony.
It by no means has the custom setting of a Pronto, but it will control the same devices with ease.