I've watched my friend's 65V10 on a few occasions, and I've never noticed flicker. Maybe the best thing to do is list all* settings here and elsewhere? I've honestly never heard of a plasma that suffered from SDE, well not for any plasma that is natively 1080p.
I am unfamiliar with all of the calibration tools on the unit. However, as you seem to be saying, there is a general setting for low mid high. It's not that simple if you want to dial it in. Basically, AFAIK, I think it's best to always check back on contrast if you dial brightness, and vice versa.
PLUGE patterns are a good place to start though. But when you do so, do it for the ambient lighting that you will use, with eyes adjusted. If you have varying amounts of light, try to set more user modes.
If the V10 is like most panny's, set it to size 2 so you don't lose out on 5% of pic due to overscan. Defeat any and all NRs (as I remember those are defaulted on certain pic modes). This in itself will clear up the pic nicely.
I don't mean to offend you with such basic info, but you never know, so I will also say that make sure 24p is engaged on both* ends, and that means the V10 and optical disc source(s).
edit: I normally use the "new posts" function, and now notice we are in the loudspeaker forum? lol