I say
1) Replace all your Mp3s with FLACs! Come on... it's easy and free! There's very little pirated music out there that's not available in at least 320kbps MP3 if not flac. WHat isn't...well... wouldn't you rather buy it and hear it well than get a crappy rip and listen to it "perked up" for your ears?!
2) Consider this:
a quality computer sound system
-Detailed active speakers
-a subwoofer that's not necessarily needed to fill a room, but also doesn't give one-note bass
-a good sound card
tends to get pretty expensive.
My advice is to instead go with a headphone/amp setup if it's just for your personal use.
Headphones - ATH-M50s (closed) or Grado SR-125 (Open) or Sennheiser HD600 (Open)
DAC - AUDINST HUD-MX1 DAC (Also serves as an amp)
Amp - Matrix M-Stage
Thing with me though is, I've got my computer hooked up to my HT Receiver via HDMI >_>
But yea, if you definitely need top notch speakers and sub, i say
1) If you can afford it, do go with the axioms. Yes they're pretty revealing and they'll make your crappy mp3s sound crappy... but they'll make your better FLACs and APEs and ALACs and even 320kbps CBRs blow you away... isn't that the point?
2) Don't go with the axiom sub though. I say go for a Dayton SUB-100 or something.. it's cheaper at least