Some homes just don't lend themselves to a hard wired run and for us a wireless solution works great. I'm using the Outlaw OWA3 which works just fine. Because it has three stereo channels you can have multiple transmitters driving 1-3 independently calibrated subs or subs and powered surrounds.
Family Rm: Samsung 52" LCD, Onkyo TX-NR809, Emotiva XPA2 & XPA-3 amps, PS3, Oppo BDP-93, FIOS HD DVR, Salk Song Tower-RT, Song Ctr-RT, Song Surrounds, SVS PB12-Plus/2, Velo SMS-1, NeoTV 550, Roku 3, Harmony-1
Bedroom: Hitachi 42" LCD, FIOS HDTV, Onkyo TX-NR906, LG BD370, NeoTV550, 3x Sierra-1 NrT (LCR), Boston VRX srds, Hsu ULS-15, SMS-1, Harmony-1
Home Office: Onkyo TX-SR707, 2x EMP E41-B, Emotiva Ultra 12 sub, and a small media server